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International Journal of Clinical Research. 2019; 3: (1) 6; DOI: 10.26855/j.ijcr.20190006.

Research Progress of the Relationship Between Ovarian Cancers and Mitochondria
卵巢癌与线粒体关系的研究进展

作者: 李欢妮,周田,曹兰琴,詹显全*

*通讯作者:詹显全,单位:中南大学湘雅医院;

引用本文: 李欢妮,周田,曹兰琴,詹显全. 卵巢癌与线粒体关系的研究进展[J]. 国际临床研究杂志, 2019, 3(1) : 26-32.
Published: 2019-09-16

摘要

促性腺激素假说和二元论假说促进了人们对卵巢癌发病机制的认识,然而其分子病理机制仍不清楚,障碍了卵巢癌的早期诊断、治疗和预后评估。线粒体作为细胞能量代谢、氧化应激和细胞信号的中心,与卵巢癌的发生、发展、治疗和预后有着密切的关系。随着线粒体蛋白质组学的发展,线粒体的分离和纯化,及其蛋白质的检测、鉴定和定量均有极大改善,有利于全面深入研究卵巢癌线粒体及其功能机制,发现以线粒体为靶点的分子标志物、药物靶点,服务于卵巢癌的早期诊断和治疗,改善其预后。

关键词: 卵巢癌,线粒体,机制,蛋白质组,蛋白质组学,分子标志物,药物靶点

Abstract

The gonadotropin hypothesis and the dualism hypothesis have promoted people's understanding of the pathogenesis of ovarian cancer. However, its molecular pathological mechanism remains unclear so that hinders the early-stage diagnosis, treatment and prognostic assessment of ovarian cancer. Mitochondria, as the centers of cellular energy metabolism, oxidative stress, and cell signaling, are closely related to the occurrence, development, treatment and prognosis of ovarian cancers. With the development of mitochondrial proteomics, the isolation and purification of mitochondria, as well as the detection, identification, and quantification of proteins have been significantly improved, which are conducive to a comprehensive and in-depth study of mitochondria of ovarian cancers and its functional mechanisms, further discovering molecular biomarkers and therapeutic targets targeting mitochondria, and contributing to the early diagnosis and treatment of ovarian cancer and improving its prognosis.

Key words: Ovarian cancer, Mitochondria, Mechanism, Proteome, Proteomics,Molecular biomarker, Therapeutic target

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